PROTEIN-LIPID COMPOSITION OF ERYTHROCYTE MEMBRANES AND METABOLISM IN CHRONIC ENDOMETRITIS
Abstract
Background: Establishment of changes in protein-lipid spectrum of erythrocyte’s membrane in CE before and after traditional complex treatment.
Materials and methods: At 38 patients in reproductive age with verified diagnosis of chronic endometritis in stage of incomplete remission, treated by traditional treatment complex, what included surgical intervention about sterility, were studied parameters of structural-functional properties of erythrocytes before and after treatment.
Results. Before treatment were established considerable changes in composition of proteins, what is in charge for structure formation and stabilization of erythrocyte’s membrane (α- and β-spectrin, dematin, ancirin, protein of a strip 4.1, pallidin), formation and flexibility of membrane (actin, tropomyosin), intracellular metabolism (anion-transporting protein, glyceraldehyde-3-phosphate dehydrogenase, glutathione-S-transferase). Were revealed disorders in maintenance and correlation of lipid spectrum, in the first place lowering of maintenance of membrane glycerophospholipids and sphingomyelins, what form base of double lipid carcass of cell membrane and play main role in arrangement of protein macromolecules and normal metabolism of erythrocytes. Defined intracellular increase of lipids peroxidation processes and maintenance of nitrogen oxides stable metabolites, lowering of activity of antioxidant defense. After treatment 9% of changed before treatment parameters were normalized, corrected, but not to normal reference ranges, 55,6%, 33,4% of indices remained the same.
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References
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